He currently plays for Osmaniyespor, wearing the number 54 shirt. He plays primarily as a Defender.

His most recent move was a from Sakaryaspor to Turk Metal Kirikkale on 2025-09-11.

Throughout the Turkish Third League 2025-2026, Yusuf Sefa Karakuzu featured in 13 matches, averaging 0 tackles, 0 interceptions, and 0 clearances per game, while blocking 0 shots per game.